Binary Data Analysis of Randomized Clinical Trials with Noncompliance

It is quite common in a randomized clinical trial (RCT) toencounter patients who do not comply with their assigned treatment.Since noncompliance often occurs non-randomly, the commonly-usedapproaches, including both the as-treated (AT) and as-protocol (AP)analysis, and the intent-to-treat (ITT) (or as-randomized)analysis, are all well known to possibly produce a biased inferenceof the treatment efficacy.This book provides a systematic and organized approach toanalyzing data for RCTs with noncom ...